The initial breakout, sometimes referred to as the ‘purge,’ experienced by some individuals commencing isotretinoin (Accutane) treatment, involves an exacerbation of existing acne as the medication accelerates skin cell turnover. This process can bring underlying inflammation and comedones to the surface more rapidly.
Minimizing this initial flare-up holds significance for patient compliance and psychological well-being during what can already be a challenging treatment period. By employing strategies to mitigate the severity of the initial breakout, dermatologists can improve the overall patient experience and adherence to the prescribed regimen. Historically, management strategies have focused on managing the breakout once it occurs, but proactive approaches are increasingly being explored.
